Two methods described for determination of Doxophylline in solid dosage form. The first method was based on UV-Spectrophotometric determination of the drug. It involves absorbance measurement at 274 nm (lmax of Doxophylline) in 0.1 N Hydrochloric acid. Calibration curve was linear with the correlation coefficient between 0.99 to 1.0 over a concentration range of 0.20 to 30 mgmL-1 for the drug. The second method was based on HPLC separation of the drug in reverse phase mode using Hypersil ODS C18 column (250 X 4.6mm, 5mm). The mobile phase constituted of Buffer: Acetonitrile (80:20) and pH adjusted to 3.0 with dilute orthophosphoric acid was delivered at the flow rate 1.0 mL min-1. Detection was performed at 210 nm. Separation was completed within 7 min. Calibration curve was linear with the correlation coefficient between 0.99 to 1.0 over a concentration range of 0.165 to 30 mgmL-1 for the drug. The relative standard deviation (R.S.D) was found