The antimicrobial activity of Volatile Oils isolated from Carum Carvi and Coriandrum Sativum were studied. The isolated Volatile Oils in varying concentrations were studied against Pseudomonas Aeruginosa and Proteus Vulgaris, by paper disc diffusion method, using Streptomycin as standard drug. The result indicated that both Carum Carvi and Coriandrum Sativum has antimicrobial potential and were active against Pseudomonous Aeruginosa selectively, while both oils were ineffective against Proteus Vulgaris.